Search scope:
排序: Display mode:
Non-genetic mechanisms of diabetic nephropathy
Qiuxia Han, Hanyu Zhu, Xiangmei Chen, Zhangsuo Liu
Frontiers of Medicine 2017, Volume 11, Issue 3, Pages 319-332 doi: 10.1007/s11684-017-0569-9
Keywords: diabetic nephropathy immune inflammatory response epithelial–mesenchymal transition apoptosis mitochondrial
Tangchun Wu
Frontiers of Medicine 2020, Volume 14, Issue 6, Pages 816-819 doi: 10.1007/s11684-020-0823-4
Frontiers of Medicine Pages 878-888 doi: 10.1007/s11684-023-0993-y
Keywords: uveal melanoma liver-directed therapy immune checkpoint blockade SIRT anti-PD-1 anti-CTLA-4
Xinghua Gao, Hongduo Chen
Frontiers of Medicine 2014, Volume 8, Issue 1, Pages 1-5 doi: 10.1007/s11684-014-0309-3
Keywords: hyperthermia HPV immune response virus tumor
Jianpeng Liu, Xinhua Chen, Shusen Zheng
Frontiers of Medicine 2021, Volume 15, Issue 2, Pages 170-177 doi: 10.1007/s11684-020-0747-z
Keywords: nanosecond pulsed electric fields (nsPEF) hepatocellular carcinoma (HCC) immune response recurrence metastasis
Integrated analysis of gut microbiome and host immune responses in COVID-19
Frontiers of Medicine 2022, Volume 16, Issue 2, Pages 263-275 doi: 10.1007/s11684-022-0921-6
Keywords: COVID-19 SARS-COV-2 gut microbiome immune response
Daniel Stadlbauer, Raffael Nachbagauer, Philip Meade, Florian Krammer
Frontiers of Medicine 2017, Volume 11, Issue 4, Pages 471-479 doi: 10.1007/s11684-017-0602-z
Keywords: universal influenza virus vaccine hemagglutinin stalk H7N9
Metformin and metabolic diseases: a focus on hepatic aspects
Juan Zheng,Shih-Lung Woo,Xiang Hu,Rachel Botchlett,Lulu Chen,Yuqing Huo,Chaodong Wu
Frontiers of Medicine 2015, Volume 9, Issue 2, Pages 173-186 doi: 10.1007/s11684-015-0384-0
Metformin has been widely used as a first-line anti-diabetic medicine for the treatment of type 2 diabetes (T2D). As a drug that primarily targets the liver, metformin suppresses hepatic glucose production (HGP), serving as the main mechanism by which metformin improves hyperglycemia of T2D. Biochemically, metformin suppresses gluconeogenesis and stimulates glycolysis. Metformin also inhibits glycogenolysis, which is a pathway that critically contributes to elevated HGP. While generating beneficial effects on hyperglycemia, metformin also improves insulin resistance and corrects dyslipidemia in patients with T2D. These beneficial effects of metformin implicate a role for metformin in managing non-alcoholic fatty liver disease. As supported by the results from both human and animal studies, metformin improves hepatic steatosis and suppresses liver inflammation. Mechanistically, the beneficial effects of metformin on hepatic aspects are mediated through both adenosine monophosphate-activated protein kinase (AMPK)-dependent and AMPK-independent pathways. In addition, metformin is generally safe and may also benefit patients with other chronic liver diseases.
Keywords: metformin diabetes hepatic steatosis inflammatory response insulin resistance
Heterologous expression of signal protein 14-3-3 in and the subsequent immune response in mice
ZHENG Meijuan, SHEN Jilong, LUO Qingli, XU Yuanhong
Frontiers of Medicine 2008, Volume 2, Issue 1, Pages 95-99 doi: 10.1007/s11684-008-0017-y
Keywords: development challenging rSj14-3-3 resistance cultural supernatant
Construction and humoral immune response of Epstein-Barr virus latent membrane protein 2 DNA vaccine
Jianqing PAN PhD, Qin ZHANG MD, Daowen WANG MD, PhD,
Frontiers of Medicine 2009, Volume 3, Issue 4, Pages 390-395 doi: 10.1007/s11684-009-0087-5
Keywords: Epstein-Barr virus latent membrane protein 2 nasopharyngeal carcinoma humoral immunity
Programming CAR T cells to enhance anti-tumor efficacy through remodeling of the immune system
Xiaohui Wang, Zhiqiang Wu, Wei Qiu, Ping Chen, Xiang Xu, Weidong Han
Frontiers of Medicine 2020, Volume 14, Issue 6, Pages 726-745 doi: 10.1007/s11684-020-0746-0
Keywords: CAR T cells immunoregulatory molecules endogenous immune response solid malignancies
Frontiers of Medicine doi: 10.1007/s11684-023-1016-8
Keywords: p53 mutation triple-negative breast cancer decitabine DNMT1 IRF7 innate immune response
Improved dissolution and anti-inflammatory effect of ibuprofen by solid dispersion
Liyuan Chen, Qifeng Dang, Chengsheng Liu, Jun Chen, Lei Song, Xiguang Chen
Frontiers of Medicine 2012, Volume 6, Issue 2, Pages 195-203 doi: 10.1007/s11684-012-0189-3
The purpose of this study was to improve the dissolution rate and anti-inflammatory effect of ibuprofenThe anti-inflammatory effect of SDBT was evaluated using the mouse ear edema test with xylene.SDBT displayed more significant anti-inflammatory effects than CT.The dissolution rate and anti-inflammatory effect of ibuprofen were significantly enhanced by the ibuprofen-urea
Keywords: ibuprofen solid dispersion physical mixture dissolution anti-inflammatory effect
Jianping Ye
Frontiers of Medicine 2015, Volume 9, Issue 2, Pages 139-145 doi: 10.1007/s11684-015-0377-z
Keywords: inflammation obesity cytokine energy expenditure insulin resistance
Yang Gao, Wen Tian, Xiaoxu Han, Feng Gao
Frontiers of Medicine 2017, Volume 11, Issue 4, Pages 480-489 doi: 10.1007/s11684-017-0594-8
Keywords: human immunodeficiency virus type I superinfection incidence immune response
Title Author Date Type Operation
Non-genetic mechanisms of diabetic nephropathy
Qiuxia Han, Hanyu Zhu, Xiangmei Chen, Zhangsuo Liu
Journal Article
Persistence of humoral and cellular immune response after SARS-CoV-2 infection: opportunities and challenges
Tangchun Wu
Journal Article
Liver-directed treatment is associated with improved survival and increased response to immune checkpoint
Journal Article
Hyperthermia on skin immune system and its application in the treatment of human papillomavirus-infected
Xinghua Gao, Hongduo Chen
Journal Article
Immune response triggered by the ablation of hepatocellular carcinoma with nanosecond pulsed electric
Jianpeng Liu, Xinhua Chen, Shusen Zheng
Journal Article
Universal influenza virus vaccines: what can we learn from the human immune response following exposure
Daniel Stadlbauer, Raffael Nachbagauer, Philip Meade, Florian Krammer
Journal Article
Metformin and metabolic diseases: a focus on hepatic aspects
Juan Zheng,Shih-Lung Woo,Xiang Hu,Rachel Botchlett,Lulu Chen,Yuqing Huo,Chaodong Wu
Journal Article
Heterologous expression of signal protein 14-3-3 in and the subsequent immune response in mice
ZHENG Meijuan, SHEN Jilong, LUO Qingli, XU Yuanhong
Journal Article
Construction and humoral immune response of Epstein-Barr virus latent membrane protein 2 DNA vaccine
Jianqing PAN PhD, Qin ZHANG MD, Daowen WANG MD, PhD,
Journal Article
Programming CAR T cells to enhance anti-tumor efficacy through remodeling of the immune system
Xiaohui Wang, Zhiqiang Wu, Wei Qiu, Ping Chen, Xiang Xu, Weidong Han
Journal Article
Decitabine induces -mediated immune responses in p53-mutated triple-negative breast cancer: a clinical
Journal Article
Improved dissolution and anti-inflammatory effect of ibuprofen by solid dispersion
Liyuan Chen, Qifeng Dang, Chengsheng Liu, Jun Chen, Lei Song, Xiguang Chen
Journal Article
Beneficial metabolic activities of inflammatory cytokine interleukin 15 in obesity and type 2 diabetes
Jianping Ye
Journal Article